Glycogen stores in glucagon-treated rats. III. Effect of adrenalectomy and hypophysectomy.

Abstract

Summary and ConclusionsThe effect of glucagon and of epinephrine on liver and muscle glycogen of adrenalectomized and hypophysectomized rats with or without treatment with cortisone or insulin was studied. 1) Epinephrine caused an immediate decrease in muscle glycogen in all cases and a decrease in liver glycogen in animals treated with cortisone. 2) In untreated adrenalectomized rats, liver glycogen was very low and further decrease due to epinephrine was not significant. Xo secondary increase in liver glycogen was noted. 3) Two hours after injection of glucagon, no significant changes in liver and muscle glycogen of untreated adrenalectomized or hypophysectomized animals were noted. 4) Twenty-four hours after the injection of glucagon in untreated adrenalectomized rats there was a significant, but very small increase in liver glycogen. Muscle glycogen was unchanged. No significant changes were noted in liver and muscle glycogen of untreated hypophysectomized rats. 5) In cortisone treated adrenalectomize...