Abstract
BackgroundGlycogen-rich carcinoma of the breast is a rare histological subtype of breast cancer, usually reported to have poor prognosis.Case presentationWe present the case of a 59-year-old woman who underwent a mastectomy for a 3.5 cm clinically palpable left breast carcinoma, originally diagnosed as fibroadenoma on a screening mammogram four years before presentation. Diagnosis of clear cell carcinoma was based on certain histological characteristics of the tumour and immunohistochemical analysis (PAS staining, keratins AE1/AE3, EMA, cytokeratin 7, cytokeratin 20, melanosomes, vimentin, Chromogranin, Synaptophysin, S-100, SMA). No lymph node metastasis was found and as the tumour was ER positive and PgR negative, patient was treated only with an aromatase inhibitor upfront and remains free of disease 48 months now since operation.ConclusionGlycogen-rich clear cell carcinoma of the breast is a rare tumor, its clinical behavior reported to be rather aggressive so far, might varies depending on special characteristics such as low grade and strongly positive ER expression
Highlights
Glycogen-rich carcinoma of the breast is a rare histological subtype of breast cancer, usually reported to have poor prognosis.Case presentation: We present the case of a 59-year-old woman who underwent a mastectomy for a 3.5 cm clinically palpable left breast carcinoma, originally diagnosed as fibroadenoma on a screening mammogram four years before presentation
Glycogen-rich clear cell carcinoma is a rare neoplasm of the breast, with an incidence of between 1.4% and 3% of all breast cancers [1,2]
We report the case of a 59-year-old woman with a slow growing tumour of her left breast, originally considered as fibroadenoma, but which proved to be a 3.5 cm glycogenrich clear cell carcinoma without lymph node involvement, four years later
Summary
Glycogen-rich clear cell carcinoma is a rare neoplasm of the breast, with an incidence of between 1.4% and 3% of all breast cancers [1,2]. We report the case of a 59-year-old woman with a slow growing tumour of her left breast, originally considered as fibroadenoma, but which proved to be a 3.5 cm glycogenrich clear cell carcinoma without lymph node involvement, four years later. A 59-year-old Caucasian woman presented with a breast mass in the upper outer quadrant of her left breast She noticed the lump on self-examination a few months before presenting to our out-patient clinic. It was not clinically palpable that time and it was thought to be a long existing benign fibroadenoma and was left in place She had full staging investigations (liver function tests, chest x-ray, computerized tomography scans of the chest and abdomen and bone scanning) which were all negative and the patient underwent an excisional biopsy, which revealed an invasive carcinoma. Hormonal therapy with the aromatase inactivator exemestane was started postoperatively and the patient is disease-free 48 months
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