Abstract
Rats were chemically sympathectomized by injecting them with 6-hydroxydopamine repeatedly during early postnatal development. Litter mates left untreated or injected with the vehicle only were used as controls. Inner ear tissues from a series of treated and control rats 11-72 days of age were fixed, then microdissected and prepared by usual methods for transmission electron microscopical study. Control rats 11 days of age showed accumulation of glycogen particles in Reissner's membrane, particularly in the epithelial cell layer near its attachment to the spiral limbus. The epithelial cells in that region also had rough endoplasmic reticulum with greatly widened cisternae containing a granular substance. The glycogen was not present after 11 days and the cisternae diminished in size with further postnatal development. The epithelial cells of the membrane in controls of all ages had intercellular clefts that were closed at the endolymphatic surface by zonulae occludentes, open narrowly at their basal end, a...
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