Abstract
γ-glutamylcysteinylethyl ester ( γ-GCE) increases reduced glutathione (GSH) levels in GSH-depleted rat hepatocytes. Because glycine, a constituent of GSH, exists at 0.3 to 0.4 mM in rat plasma, we examined the influence of glycine added to the medium on the action of γ-GCE to increase GSH levels in the rat hepatocytes. Glycine (0.2-0.8 mM) dose-dependently enhanced γ-GCE-mediated increase in intracellular GSH levels with an increase in intracellular γ-GCE levels. These results indicate that exogenous glycine facilitates γ-GCE-mediated increase in intracellular GSH levels in rat hepatocytes possibly by enhancing the uptake of γ-GCE into the cells.
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