Glycine application in the treatment of patients with adjustment Disorders

Abstract

Manifestations of mental maladaptation play an important role in diagnosing the consequences of stressful situations, and methods of their treatment include a wide range of therapeutic interventions. This paper describes a randomized placebo-controlled study of the efficacy and tolerability of the drug glycine based on a pharmaceutical composition of microencapsulated glycine and magnesium stearate in adjustment disorder with a predominance of disturbances in other emotions. In the glycine group, 82.4 % of patients achieved a significant improvement in the CGI score, while in the placebo group, this figure was 14.3 %. Glycine was safe and well tolerated by patients, none of the patients was prematurely excluded due to adverse events. The results of the study confirm the effectiveness of glycine and its superiority over placebo in this sample of patients with an improvement in all measured parameters.