Abstract
1. Specific high-affinity binding of [3H]glycine (KB ≅ 1−1.8 × 10−7 M; Bmax ≅ 0.8−2.1 nmoles/g pellet) occurred to synaptosome-enriched fractions of 6 regions of rat CNS.2. Strychnine-sensitive and strychnine-insensitive glycine binding sites appeared to exist. Strychninesensitive sites had KB ≅ 0.2−0.8 × 10−7 M and Bmax ≅ 0.2−0.55 nmole/g pellet.3. About 565–1370 pmoles/g, original weight of tissue, of specific glycine sites and about 109–358 pmoles/g of strychnine-sensitive glycine sites were present in various CNS regions.4. These findings provide a direct approach for examining the properties of glycine-receptors.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
