Abstract
AbstractIn this study, glycerol‐1,2‐carbonate was employed as a convenient reagent for the synthesis of more complex pyrazole‐containing heterocyclic systems. 3‐O‐Tosylated glycerol‐1,2‐carbonate (TGC) was used for alkylation of NH‐pyrazolecarboxylates. The obtained N‐glycerylated pyrazoles were further treated with diverse nucleophiles for 2‐oxo‐1,3‐dioxolane ring cleavage. The synthesized 1‐(2,3‐dihydroxypropyl)‐1H‐pyrazole‐5‐carboxylates were subsequently hydrolyzed and treated with p‐toluenesulfonic acid, yielding a series of 6‐(hydroxymethyl)‐6,7‐dihydro‐4H‐pyrazolo[5,1‐c][1,4]ox‐azin‐4‐ones.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
