Abstract
AbstractA convenient, eco‐friendly, one‐pot, multi‐component synthesis of new 2, 4‐disubstituted hydrazinyl ‐ thiazoles under mild reaction conditions has been disclosed. The use of micellar catalysis in glycerol is the key aspect of this methodology which possesses superiority compared to glycerol alone. The other significant aspect of our findings is the use of inexpensive reagents, recyclability, mild reaction conditions, bioorganic compound as solvent cum promoter, short reaction time, high yield, column chromatography free etc. The present work proposes the construction of a variety of biologically active 2, 4‐disubstituted thiazole derivatives using different carbonyl compounds, thiosemicarbazide and α‐bromocarbonyl compounds. Due to its operational simplicity, this green and unexplored protocol can be easily applied for designing novel biologically active compounds.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
