Abstract
A green, metal-free and facile protocol has been developed by the three-component reaction of dimethyl acetylenedicarboxylate, aromatic amines and aldehydes with C-SO3H as an effective catalyst to afford diverse substituted dihydrofuran-3-carboxylates in high yields. The prominent features of this protocol are the catalyst reusability, wide range of functional group tolerance, shorter reaction time, no column chromatographic purification and easy work-up. The present one-step, cascade synthetic approach is straight forward that could avoid hazardous reagents and is turned to be a benign chemistry for the preparation of potent furan based molecules on a large scale.
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