Glycemic control with intensive insulin treatment fundamental to renal preservation in diabetes

Abstract

D is the most common cause of end stage renal disease (ESRD).Previous studies imply angiotensin converting enzyme inhibitor (ACEI) and angiotensin receptor blocking (ARB) drugs contribute to prevalence of ESRD in diabetes. This study investigates renal preservation in diabetes by intensive insulin therapy. Methodology: 46 adult diabetes patients, 28 female, 18 male, were studied for mean 14.2 months (1.5-115 months). Diabetes was diagnosed by 2-h postprandial glucose of ≥ 200mg/dL (11.1 mmol/L) and treated by Glargine or detemir insulin after breakfast and dinner, with regular insulin by finger-stick glucose 2-h post-meal and bedtime. Blood pressure (BP) was controlled with antihypertensive therapy excluding ACEI/ARB drugs. Glucose, serum creatinine (Scr), estimated glomerular filtration rate (eGFR), and glycosylated hemoglobin at first and last visits were obtained. BP was recorded in both visits. Results were compared between first and last visits. A paired two-tailed test P 11.1 mmol/L. Results: Glucose at last visit was significantly lower (8.4±0.6 mmol/L) than first visit (10.3±0.7 mmol/L) in all patients group associated with significantly reduced Scr in last visit (100.3±5.2 μm0l/L) compared to first visit (110.9+7.8 μmol/L). No change in eGFR was noted between first and last visits. Significant reduction of HbA1c (9.14±0.52 v. 7.60±0.45 p< 0.0148) was found in less than 11.1 mmol/L group. BP’s were normal (<140/80mmHg) in both visits in all groups. Conclusion: The paradigm of therapy presented in this study is proven effective in renal preservation in diabetes. Anil K. Mandal et al., Altern Integ Med 2013, 2:10 http://dx.doi.org/10.4172/2327-5162.S1.002