Glycated Hemoglobin is a Biomarker of Renal Failure in Diabetic Patients

Abstract

Objective: In diabetic patients, this condition leads the cause the chronic kidney disease commonly known as diabetic nephropathy or diabetic kidney disease. Diabetic kidney disease patients were an exceptional cohort of the population that had a noticeable high glycated hemoglobin along with a low glomerular filtration rate. Methodology: The recent cross-sectional study was based on a 790 participants sample size, having both normal and diabetic patients with various complications and severities related to renal function. This research is based on diabetes mellitus type 2 patients under the treatment in Farwaniyah hospital, Kuwait from 2007 to 2010. The patients were divided into four groups based on Diabetic + Renal failure (Diab+RF), Diabetic + non-Renal failure (Diab+ NRF), Nondiabetic +Renal failure (NDiab +RF) compared with normal individuals. Correlations were evaluated between HbA1c with all groups and the estimated glomerular filtration rate. Results: In this study, we observed that higher HbA1c may the reason for the decline in glomerular filtration rate, irrespective of general characteristics like age, sex, and Blood Pressure. Our results showed that 37% of diabetic patients with renal failure. Conclusion: We report that in clinical exercise glycated hemoglobin acted as a biomarker to predict the renal disease stage. Control glucose restricts the decline in glomerular filtration rate this act shows the value of glycemic variability in glomerular filtration rate descent. endothelial damages cause by High glycated hemoglobin levels with low plasma glucose in fasting.