Abstract
Glycated Hemoglobin A1c (HbA1c) has been widely recognized as a biomarker predictor for the severity of Diabetes Mellitus (DM). Glycated Hemoglobin (HbA1c) is a pivotal biomarker reflecting both fasting and postprandial plasma glucose concentration over the preceding 120 days. It has been regarded as an important tool in diabetes diagnosis and management. Elevated HbA1c levels probably mean longterm insulin resistance and severe consequences such as hyperglycemia, dyslipidemia, hypercoagulability, and inflammatory response. There is a positive relationship between elevated HbA1c and poor outcome not only in DM, but also Cardiovascular Disease (CVD) and inflammation. It is said that HbA1c is a biomarker predictor in several ways as molecular aspects through hyperglycemic environtment increasing apoptosis of polymorphonuclear leukocytes and production of inflammatory cytokines.
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