Glycal–ruthenium carbonyl clusters: Syntheses, characterization, and anticancer activity

Abstract

Four new chiral ruthenium carbonyl cluster complexes Ru 3(μ-H) 2(CO) 9(L-2H) ( 1), Ru 3(μ-H) 2(CO) 7(L-2H)(dppm) ( 2) , Ru 3(μ-H) 2(CO) 7(L-2H)(PPh 3) 2 ( 3) , Ru 3(μ-H) 2(CO) 7(L-2H)(dppe) ( 4) containing a dehydrogenated form (L-2H) of 3,4,6-tri- O-benzyl- d-galactal (L) as a chiral ligand have been prepared and characterized. The anticancer activity of five compounds 1–4 and Ru 3(μ-H) 2(CO) 9(L-2H) 5 (L = tribenzyl glucal) against six types of human cancer cell lines was studied and compared to cisplatin. Compound 1 was chosen to produce more detailed growth curves based on overall highest activity profile. The structure of compound 2 was established by a single-crystal X-ray diffraction analysis. The structure based on triangular metal framework contains a bridging dehydrogenated tribenzyl galactal ligand bonded in a parallel μ 3-η 2-bonding mode and a bridging dppm ligand. Variable-temperature NMR studies show that the two hydride ligands in compounds 1 and 2 are dynamically active on the NMR time scale at room temperature.