Gly-Pro и адаптивные реакции при многокомпонентном стрессе

Abstract

Here, we studied the effect of the Gly-Pro peptide on the reactivity and adaptive potential during the stimulation of the parasympathetic nervous system by carbachol under the conditions of successive combined effects of three stressors: immobilization, surgical intervention, and the injection procedure. Consistent combined effect of the surgical intervention in the form of the ligature application to the pyloric stomach, the immobilization, and the saline injection procedure under the carbachol allowed to identify 4 typer of responses. These types were characterized by different combinations of corticosterone contents, and separate leukocyte subpopulations. All responses were accompanied by the stress development, as indicated by the adaptation intensity index. The most prominent stress reactions were observed in animals after the immobilization and surgery, and the combined effects of saline and carbachol injections. Through the modulation of the parasympathetic link of the autonomic nervous system, and probably the direct effect on the adrenal glands, Gly-Pro changed the corticosterone levels, individual leukocyte subpopulations, and the adaptation intensity index under multicomponent stress. In the case of the simultaneous peptide and carbachol administration, it apparently activated the resistant (resistance, counteraction) pathway of adaptation, and in the case when it was administered before carbachol, – the tolerance (endurance, patience) pathway.