Abstract
The thiol-oxidizing agent, DIP(diazenedicarboxylic acid bis (N′-methylpiperazide), I) and its homologs with different N'alkyl groups can be utilized to obtain membrane diffusion coefficients for human erythrocytes at 1°. From the initial rates of intracellular glutathione (GSH) oxidation and the 2-octanol partition coefficients for the specific DIP homolog, diffusion coefficients of ca. 1 × 10−8cm2/sec are obtained. The method (irreversible loss of permeant through well-defined intracellular reaction) can be used to evaluate membrane properties and possibly for the study of substituent effects on drug entry into cells.
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