Abstract
Objective:Human papillomavirus (HPV) infection is an important sexually-transmitted infection worldwide. Persistent infections with different high-risk HPV genotypes may cause cervical intraepithelial neoplasia and cervical cancer. Single nucleotide polymorphisms of glutathione S-transferase omega (GSTO) 1 and 2 play an important role in cancer progression. To evaluate GSTO gene polymorphism influence on women’s susceptibility to low-risk or high-risk HPV infections and also risk of cervical cancer development.Material and Methods:We examined 50 patients with cervical cancer, 43 patients who were positive for HPV, and 43 healthy individuals as negative controls. We used polymerase chain reaction-restriction fragment length polymorphism to determine GSTO1 A140D and GSTO2 N142D variants in study participants.Results:We found a significant association between the GSTO1 A140D gene polymorphism and HPV 6, 16, 18, 16/18 infections and cervical cancer in Iranian women. We noted a significant difference for the 140AD/142NN combination genotype between patients in the cervical cancer group and healthy controls. There were no significant differences for the GSTO2 N142D genotype and allele frequencies between the patient (i.e., cervical cancer and HPV-positive) groups and controls.Conclusion:The 140AD genotype, 140D allele, and 140AD/142NN combination genotype seem to confer a protective property in women’s susceptibility to HPV 6, 16, 18, 16/18 infections and cervical cancer. However, the GSTO2 N142D polymorphism is not associated with HPV infections and cervical cancer. It would appear that GSTO1 A140D SNPs likely play a role in the level of susceptibility to HPV-related cervical cancer.
Highlights
Human papillomavirus (HPV) infections constitute a large portion of sexually-transmitted disease cases worldwide, and up to 70% of sexually active women are infected by HPV during their lifetime
No GST omega (GSTO) gene polymorphisms have been explored between HPV infection and genital cancers, but some studies have investigated the interaction between these Single nucleotide polymorphisms (SNPs) and many diseases such as sporadic Alzheimer’s disease, cerebrovascular atherosclerosis, and obstructive pulmonary disease [18]
The GSTO1 A140D and GSTO2 N142D genotypic frequencies of the HPV-negative control group were in Hardy-Weinberg equilibrium (χ2= 1.91 and 0.452, respectively)
Summary
Human papillomavirus (HPV) infections constitute a large portion of sexually-transmitted disease cases worldwide, and up to 70% of sexually active women are infected by HPV during their lifetime. The variation seen in the occurrence of HPV infection in different regions of the world demonstrates that HPV is the main cause of cervical cancer, environmental and Glutathione S-transferase omega gene polymorphism. Single nucleotide polymorphisms (SNPs) of this super family can affect the likelihood of cancer development and the chances of success for various treatments [14]. The most frequent missense polymorphism in the GSTO1 gene is the Ala140/Asp substitution. This substitution can be found in all populations. No GSTO gene polymorphisms have been explored between HPV infection and genital cancers, but some studies have investigated the interaction between these SNPs and many diseases such as sporadic Alzheimer’s disease, cerebrovascular atherosclerosis, and obstructive pulmonary disease [18]
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