Abstract
The relationship between glucose-6-phosphate dehydrogenase activity and glutathione stability was studied in red cells of different ages. A direct relationship between glutathione stability and glucose-6-phosphate dehydrogenase activity could be demonstrated in red cells from enzyme-deficient patients as well as in those with normal levels of enzyme activity. Relative differences in these relationships between normal and enzyme-deficient cells provide support for the view that decreased glutathione stability reflects not only glucose-6-phosphate dehydrogenase deficiency but also some other unknown defect associated with aging.
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