Glutathione S-transferase M1 null genotype and hepatocellular carcinoma susceptibility in China and India: evidence from an updated meta-analysis.

Hong-Zhou Liu,Jie Peng,Chun-Yan Peng,Ming Yan,Fang Zheng

doi:10.7314/apjcp.2014.15.12.4851

Abstract

Glutathione S-transferase M1 (GSTM1) have been reported to be associated with hepatocellular carcinoma. However, the effect of the GSTM1 null genotype was divergent in the literature and we therefore performed the present meta-analysis to explore the relationship in detail. Reported studies were searched from 1990 to March 1, 2014 in PubMed and Wanfang Med Online. The total odds oatio (OR) and 95% CI were calculated and analyzed by Review Manager 5.1 and STATE 12. Total OR was calculated from 26 articles with 3,769 cases and 5,517 controls and the association proved significant (OR [95%CI]=1.50 [1.25, 1.80], P<0.05) in the Chinese population. However, there was no significant association between hepatocellular carcinoma risk among subjects carrying the GSTM1 null genotype (OR [95%CI]=1.20 [0.88-1.64], P=0.24) in subgroups of publication in English and in Indian populations (OR [95%CI]=1.80 [0.80- 4.20], P=0.15). The GSTM1 deletion polymorphism might not have a significant effect on the susceptibility of hepatocellular carcinoma overall.

Highlights

Liver cancer was the most common cancer and a serious fatal disease and had caused serious damage to human health (Yu et al, 2011)
The effect of the Glutathione S-transferase M1 (GSTM1) null genotype was divergent in the literature and we performed the present meta-analysis to explore the relationship in detail
Some studies were about genetic polymorphisms and suggested that GSTM1 deletion polymorphism was involved in liver cancer risk in China (Wang et al, 2010; Yu et al, 2011; Chen et al, 2012; Liu et al, 2013)

Summary

Introduction

Liver cancer was the most common cancer and a serious fatal disease and had caused serious damage to human health (Yu et al, 2011). Only a minority of subjects who carried GSTM1 null genotype developed liver cancer. This phenomenon suggested that other risk factors, such as other genes polymorphisms, were related to susceptibility to liver cancer (Lakkakula et al, 2013). GSTM1 was hypothesized to protect against toxins Many enzymes, such as cytochrome P450 (CYP450), microsomal epoxide hydrolase, and N-acetyltransferase, ZHUHLQYROYHGLQGHWR[LÀFDWLRQRIFDUFLQRJHQV:HGRXEW that GSTM1 null genotype was the etiology of liver cancer. We did this meta-analysis to investigate the effect of GSTM1 null genotype in etiology of liver cancer by subgroup analysis of publication language. We enlarged the number of cases and controls to do an undated meta-analysis, and we ruled out publication bias by using subgroup analysis of publication language to make the conclusion more convincing

Materials and Methods

Results

Discussion