Abstract
Background and objective Breast cancer remains the most common cause of cancer mortality in women. The aim of this study was to investigate associations between genetic variability in GSTM1 and GSTT1 and susceptibility to breast cancer. Methods Genomic DNA was extracted from blood samples for 80 cases of histologically diagnosed breast cancer and 100 control subjects. Genotyping analyses were performed by PCR-based methods. Associations between specific genotypes and the development of breast cancer were examined using logistic regression to calculate odds ratios [1] and 95% confidence intervals (95%CI). Results No correlation was found between GSTM1-null and breast cancer (OR = 1.83; 95%CI 0.90-3.71; p = 0.10), while GSTT1-null (OR = 2.42; 95%CI 1.17-5.02; p= 0.01) was associated with increased breast cancer risk. The GSTM1/GSTT1 double null was not associated with an increased risk of developing breast cancer (OR = 2.52; 95%CI 0.75-8.45; p = 0.20). Furthermore, analysis found no association between GSTM1-null (OR =1.12; 95%CI 0.08-15.50; p = 1.00) or GSTT1-null (OR = 1.71; 95%CI 0.13-22.51; p = 1.00) and the disease stage of familial breast cancer patients or sporadic breast cancer patients (GSTM1 (OR = 0.40; 95%CI 0.12-1.32; p = 0.20) and GSTT1 (OR = 1.41; 95%CI 0.39-5.12; p = 0.75)). Also, body mass index (BMI) was not associated with increased or decreased breast cancer risk in either GSTM1-null (OR = 0.60; 95%CI 0.21-1.68; p = 0.44) or GSTT1-null (OR = 0.60; 95%CI 0.21-1.68; p =0.45). Conclusion Our results suggest that only GSTT1-null is associated with increased susceptibility to breast cancer development.
Highlights
According to GLOBOCAN 2018 (Cancer database), there are about 2.1 million newly diagnosed female breast cancer cases worldwide each year, making up 11.6% of all cancer diagnoses
No correlation was found between GSTM1null and breast cancer (OR = 1.83; 95% confidence intervals (95%CI) 0.90-3.71; p = 0.10), while GSTT1-null (OR = 2.42; 95%CI 1.17-5.02; p= 0.01) was associated with increased breast cancer risk
Based on studies investigating the association of GSTT1 and GSTM1 variants with breast cancer risk, as well as on the role of glutathione S-transferases (GSTs) in inactivating endogenous metabolites during oxidative stress and its influence on the normal functions of mammalian tissues, we investigated the distribution of GSTM1 and GSTT1 variants in patients with histologically diagnosed breast cancer in comparison to controls to explore the possible association of GST genotypes and risk of breast cancer development
Summary
According to GLOBOCAN 2018 (Cancer database), there are about 2.1 million newly diagnosed female breast cancer cases worldwide each year, making up 11.6% of all cancer diagnoses. In 2018, breast cancer was the cause of 626,679 (6.6%) deaths, accounting for almost 1 in 4 cancer cases among women [2]. 176 Isabelle Touwendpoulimdé Kiendrebeogo et al: GSTM1/GSTT1 variants and Breast Cancer cause of cancer mortality in women, and it constitutes an important health problem [2]. Research has suggested that risk factors for breast cancer are environmental, genetic, nutritional (diet), and hormonal. Environmental factors have been well-reported in many breast cancers studies. These environmental factors include carcinogens, xenoestrogens and chemical mutagens [3]. Breast cancer remains the most common cause of cancer mortality in women. The aim of this study was to investigate associations between genetic variability in GSTM1 and GSTT1 and susceptibility to breast cancer
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