Abstract
We observed inconsistent conclusions regarding the genetic role of glutathione S-transferase gene polymorphisms, including glutathione S-transferase M1 (GSTM1), glutathione S-transferase T1 (GSTT1) present/null, and glutathione S-transferase pi (GSTP1) Ile105Val polymorphisms, in the susceptibility to nasal or colorectal polyposis (NP or CP). Thus, we aimed to perform a meta-analysis to comprehensively evaluate this association by applying Stata/SE software. After the heterogeneity assumption, Mantel–Haenszel statistics were used to obtain the odds ratio (OR), 95% confidence interval (95% CI) and P-value of the association test (PA). We obtained a total of 235 articles by searching online databases. After screening, ten eligible case–control studies were finally enrolled in our meta-analysis. For the meta-analysis of the GSTT1 gene under present versus null, we observed a decreased risk of NP [OR = 0.65; PA=0.018], but not CP. In addition, we did not detect any evident association between the GSTM1 present/null polymorphism and NP or CP risk. For the meta-analysis of the GSTP1 Ile105Val polymorphism, compared with controls, an increased risk of NP cases was detected under the models of Val versus Ile (OR = 1.36; PA=0.027), Ile/Val versus Ile/Ile (OR = 1.70; PA=0.011) and Ile/Val+Val/Val versus Ile/Ile (OR = 1.65; PA=0.010). In conclusion, the null genotype of the GSTT1 polymorphism may be linked to an increased susceptibility to NP, whereas the Ile/Val genotype of the GSTP1 Ile105Val polymorphism may be associated with a decreased risk of NP.
Highlights
Polyposis refers to a chronic disorder characterized by the presence of polyps, which are neoplasms that grow on the mucosal surface of human organs or tissues, including the nasal cavity, vocal cord, stomach, or colorectal area [1–3]
nasal polyposis (NP) is thought to be closely associated with a group of clinical disorders characterized by chronic rhinosinusitis and shows differences in complexity and etiology [1,23,24]
A family-based genome-wide association study reported that the holocarboxylase synthetase (HLCS), major histocompatibility complex, class II, DR α (HLA-DRA), BICD cargo adaptor 2 (BICD2), V-set immunoregulatory receptor (VSIR), and solute carrier family 5 member 1 (SLC5A1) genes may be linked to the pathogenesis of chronic rhinosinusitis with nasal polyps [9]
Summary
Polyposis refers to a chronic disorder characterized by the presence of polyps, which are neoplasms that grow on the mucosal surface of human organs or tissues, including the nasal cavity, vocal cord, stomach, or colorectal area [1–3]. NP, a chronic and complicated inflammatory disorder with the formation of mostly benign polyps within bilateral nasal cavities, encompasses a series of pathological features, such as epithelial cell proliferation, eosinophil infiltration, and glandular changes [4,5]. Colorectal polyps are mostly regarded as a type of benign tumor, but some show malignant tendencies, and the removal of polyps is an effective approach to prevent the occurrence of cancer [6]. The exact etiology of polyposis remains to be elucidated, chronic stimulation and genetic factors may partly account for the presence of polyps [7,8]. Genetic variants reportedly involved in the complicated etiology or pathogenesis of NP or CP are increasingly reported [7,9,10]
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