Abstract
1. The epimastigotes of Trypanosoma cruzi catalyze in vivo and in vitro the conjugation of styrene oxide and 1-chloro-2,4-dinitrobenzene at substantial rates. 2. Conjugation of drugs possessing an electrophilic grouping to the thiol group of glutathione may represent an important detoxication factor in the resistance of the parasite to known antiprotozoal agents.
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