Abstract
The effect of some factors influencing the metabolism of xenobiotics on the glutathione content as well as the glutathione S-transferase activities towards 1-chloro-2,4-dinitrobenzene (aryl substrate) and 1,2-epoxy-3-(p-nitrophenoxy)propane (epoxide substrate) were studied in rat liver cytosol. Metabolic inducers (phenobarbital, rifampicin, DDT) as well as fasting led to marked increases in both glutathione transferase activities. Partial hepatectomy, acute and chronic alcohol pretreatment, experimental diabetes and thyroid dysfunction resulted in a more or less pronounced increase in the epoxide transferase activity whereas the aryl transferase remained unaffected. Experimental cholestasis and liver pre-injury following the administration of CCl4 decreased the glutathione S-transferase activity towards the epoxide substrate but not that towards the aryl substrate.
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