Glutathione Peroxidase Level in Patients with Vitiligo: A Meta-Analysis.

Bi-Huan Xiao,Yan Wu,Hong-Duo Chen,Xing-Hua Gao,Meihui Shi,Hongqiang Chen,Shaoshan Cui

doi:10.1155/2016/3029810

Abstract

Abnormality of glutathione peroxidase (GPx) is involved in the etiology and pathogenesis of vitiligo. However, the results were controversial. Aim. The purpose of this meta-analysis is to compare the levels of GPx between vitiligo patients and healthy controls. Methods. Relevant published articles were searched according to eligibility criteria. A meta-analysis was conducted to pool estimates of the standardized mean difference (SMD) with 95% confidence interval (CI). Results. Twenty-three studies with a total of 1076 vitiligo patients and 770 healthy controls were included. The pooled meta-analysis showed that patients with vitiligo had equivalent levels of GPx with the healthy controls (SMD = −0.47, 95% CI: −1.03 to 0.08, and p = 0.095). Further subgroup analysis showed that the GPx levels of Asian patients or segmental vitiligo patients were, respectively, lower than those of healthy controls (Asian: SMD = −0.47, 95% CI: −1.08 to 0.14, and p = 0.001; segmental: SMD = −3.59, 95% CI: −6.38 to −0.80, and p = 0.012). Furthermore, the GPx levels in serum/plasma were significantly decreased in either stable or active vitiligo patients, comparing to healthy controls (stable: SMD = −2.01, 95% CI: −3.52 to −0.49, and p = 0.009; active: SMD = −2.34, 95% CI: −4.07 to −0.61, and p = 0.008). Conclusion. This meta-analysis showed a significant association between low GPx level and vitiligo.

Highlights

Vitiligo is an idiopathic, acquired pigmentation disorder of skin and/or mucosa, with clinical manifestations of porcelain white patches
The results indicated that patients with vitiligo had equivalent levels of glutathione peroxidase (GPx) with the healthy controls (SMD = −0.47, 95% confidence interval (CI): −1.03 to 0.08, and p = 0.095) (Figure 2)
The results indicated that the vitiligo patients at either stable stage or active stage had lower GPx levels in serum/plasma compared to controls (Figures 4(a) and 4(b))

Summary

Introduction

Vitiligo is an idiopathic, acquired pigmentation disorder of skin and/or mucosa, with clinical manifestations of porcelain white patches. It is considered to be a multifactorial and polygenic disease caused by the destruction of melanocytes [1]. Oxidative stress is considered to be one of the causative factors in the pathogenesis of vitiligo [2]. Glutathione peroxidase (GPx) is the general name of an enzyme family with peroxidase activity. It protects cells from oxidative damage through decreasing lipid hydroperoxides to their corresponding alcohols or reducing free hydrogen peroxide to water [3]. Many researches about this antioxidant marker have been sought, but the conclusions were conflicting. Some researchers reported elevated level, whereas others showed no change or reduced level. Due to the inconsistent results, we do the meta-analysis to clarify the GPx level in vitiligo patients

Methods

Results

Conclusion