Abstract
New thiol-oxidizing agents, DIP (diazene dicarboxylic acid bis(N′-methylpiperazide), DIP+1(N′-methyl iodide salt of DIP), and DIP+2 (bis-N′-methyl iodide salt of DIP) have been applied to human red blood cell suspensions. At 20°C, DIP leads to fairly rapid oxidation of intracellular glutathione, GSH. Although both DIP+1 and DIP+2 are slightly more reactive towards GSH than DIP, neither agent causes any change in intracellular GSH. Possible applications of the new series are outlined.
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