Abstract
The developmental aspects of glutathione in the mouse fetal liver and the relative roles of glutathione in maternal liver, placenta and fetal liver int he protection against possible harmful effects of acetaminophen were studied. The glutatione concentration in the fetal mouse liver is significantly less than that in adult liver and reaches the adult levels about 10 days after birth. The rate of depletion of glutathione after acetaminophen administration reaches the adult levels about 15 days after birth. Treatment with 3-methylcholanthrene (MC) enhances the rate of glutathione depletion in both maternal and fetal livers of the genetically responsive C57BL/6N mouse, but not in the gentically nonresponsive AKR/N mouse. No teratogenic effects of acetaminophen were observed at doses between 100 and 250 mg kg −1 given between days 6 and 13 of gestation.
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