Abstract
Identification of redox markers may be of clinical significance in the management of dengue patients. This study is to identify the association between antioxidant enzymes, hematological parameters and liver transaminases in patients with acute dengue infection. Blood samples were taken from patients on the day of admission, day 05 and 07 from admission for analysis of glutathione peroxidase (GPX), glutathione reductase (GR), aspartate transaminase (AST), alanine transaminase (ALT) and hematological parameters. AST and ALT levels were significantly elevated (p < 0.05) on day 05 in dengue patients. In contrast, GPX and GR showed significantly low levels on day 05 compared to on the day of admission and day 07. Although there was a decline in the trend of platelets towards day 05, values were not significantly different. Dengue associated with liver injury appears to peak around day 05 when the GPX and GR enzymes levels in patients were the lowest suggesting that increased viral load in the acute phase of dengue infection has initiated an antioxidant imbalance. Thus, timely investigation of antioxidant enzymes (GR and GPX) and liver transaminases around day 05 of admission may be of value in the management of patients with dengue infection similar to as seen in platelet counts.
Highlights
Dengue virus is a major mosquito-borne disease worldwide, with a thirty-fold increase in incidence during the past 50 years [1]
Redox disequilibrium is associated with pathology of cardiovascular [20], diabetes and cataracts [19] [21] in our previous studies, where erythrocyte glutathione peroxidase (GPX) activity was found to be a sensitive marker of oxidative stress
This study was carried out to determine the changes in blood antioxidant enzymes (GR and GPX) in parallel with liver transaminases and other hemaotological parameters in acute phase of dengue viral infection
Summary
Dengue virus is a major mosquito-borne disease worldwide, with a thirty-fold increase in incidence during the past 50 years [1]. The severity of dengue infection varies widely, suggesting immune pathological, genetic and viral type factors may play a role in disease severity [6] [7] [8] [9]. Host genetic factors, such as glucose 6-phosphate dehydrogenase deficiency, may contribute to increased replication of dengue virus in monocytes, which effect abnormal cellular redox equilibrium. Inactivation and removal of these ROS depend on relations involving a wide spectrum of antioxidative defense mechanisms These ROS are neutralized by various mechanisms; GPx and GR have been reported to be a more sensitive antioxidant enzyme in dengue and other viral infections [15]. We decided to investigate the association of GR and GPX activity with respect to liver damage in acute dengue infection by using aspartate transaminase (AST) and alanine transaminase (ALT)
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