Abstract
In your April issue, two distinguished groups of radiobiologists expressed diametrically opposed views on glutathione (GSH) depletion and misonidazole (MISO) efficiency (Brown & Bump, 1985; Shrieve & Denekamp, 1985). I would like to offer some suggestions which might lead to a resolution of this conflict. Firstly, there are questions of semantics. How do we define “additive”, a word which Brown and Bump use on six occasions? “Additive” sounds simple enough, but unfortunately this expression is dangerously ambiguous (Scott, 1961). It can be used to describe (A) similar joint action, or (B) independent joint action (Goldin & Mantel, 1957). The fuzziness surrounding the idea of additivity was encapsulated in the “Envelope of additivity” by Steel and Peckham (1979). Note that Goldin and Mantel's type B corresponds to Steel and Peckham's Mode 1.
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