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Abstract
1. 1. The effect of glutathione (GSH) depletion on rabbit renal medullary homogenate 6-ketoPGF 1α and TxB 2 synthesizing capability was investigated. 2. 2. GSH depletion in vivo with diethyl maleate (DEM) produced higher ( P < 0.05) 6-ketoPGF 1α and TxB 2 renal medullary levels compared to controls. Homogenization and incubation lowered ( P < 0.05) GSH such that there were no differences in GSH between treatments after 5 min of incubation. By 30 min, GSH was lower ( P < 0.05) and 6-ketoPGF 1α higher ( P < 0.05) in homogenates from controls in comparison to those from DEM-treated rabbits. 3. 3. The results indicate GSH depletion increased 6-ketoPGF 1α levels in rabbit renal medulla in vivo but subsequent GSH catabolism prevented assessing the effect of this GSH depletion on prostanoid synthesizing capability.
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