Abstract
The present communication presents evidence showing that rat liver degrades 2,2-dichlorovinyl dimethyl phosphate (DDVP or Vapona) by two main enzymatic pathways. The first one produces 2,2 dichlorovinyl monomethyl phosphate (des-CH 3-DDVP) and it is glutathione- dependent. The second enzymatic system metabolizes DDVP to dimethyl phosphate and dichloroacetaldehyde and it is glutathione-independent. The degradation of des-CH 3-DDVP to dichloroacetaldehyde and monomethyl- phosphate is also glutathione-independent. The role of reduced-glutathione in the degradation of organophosphorous compounds is discussed.
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