Abstract

Glutaredoxin (Grx) maintains and regulates the cellular redox state and redox‐dependent signaling pathways. Grx has been implied in various disease‐related conditions. The human Grx family has four distinct members (Grx1‐3 and Grx5) in various subcellular locations. We investigated levels of expression of all Grx genes in various cancer tissues by real‐time polymerase chain reaction. Levels of Grx2 and Grx5 messenger RNA (mRNA) in breast cancer tissue exceeded that in other solid cancers. Moreover, the level of Grx2 mRNA in breast cancer was the highest among those of other mRNAs including Grx, thioredoxin (Trx1, Trx2), and peroxirdoxin (Prx I‐VI) families. Among members of the Grx family, Grx3 gene was preferentially induced in lung and colon, whereas not in thyroid, lymphoma, liver, and kidney. Western blot analysis of different and paired breast tissues revealed consistent and preferential expression of Grx3 in lung and colon cancers. The expression of Grx3 gene was correlated with that of survivin gene, suggesting its reverse‐association with apoptosis. Taken together, the striking and preferential inductions of Grx2 in breast cancer and Grx3 in lung and colon may enable their use as corresponding cancer markers. *This work was financially supported by Regional Research and Development Cluster Project (B0009735) funded by the Ministry of Knowledge Economy (MKE) of Korea.

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