Abstract
Pretreatment of hippocampal slices with glutamine doubled the recovery rate of the synaptic function (electrically evoked population spike) from a standardized hypoxic insult in CA 1 pyramidal neurons. This protective effect of glutamine was dose-dependent and biphasic; recovery of synaptic function was observed in 44% of the control slices and in 55%, 90%, 92% and 0% of slices pretreated with 0.1, 1.0, 5.0 and 10.0 mM glutamine, respectively. The synaptic function did not recover after hypoxia in slices pretreated with glutamic acid (1.0 mM).
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
