Abstract
RECENT results of in vivo experiments using glutamic acid labelled with carbon-14 were consistent with the hypothesis that the amidation of the administered amino-acid to glutamine represents a metabolic event occurring in a tissue or cellular compartment1,2. Since glutamic acid and glutamine syntheses in the central nervous system are the two known processes by which ammonia enters organic linkage, it appeared of great interest to approach the question of setting into compartments the metabolism of glutamic acid and its derivatives with the aid of ammonia labelled with nitrogen-15.
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