Glutamate receptor gene GRIN2A, coffee, and Parkinson disease.

Taye H Hamza,Stewart A Factor,Jeffrey M Vance,Haydeh Payami,Erin M Hill-Burns,William K Scott,Cyrus P Zabetian

doi:10.1371/journal.pgen.1004774

Abstract

Glutamate receptor gene GRIN2A, coffee, and Parkinson disease.

Highlights

The first evidence for involvement of glutamate receptor gene GRIN2A came from a genome-wide association and interaction study (GWAIS) that suggested that the protective effect of coffee against Parkinson disease (PD) is stronger in carriers of GRIN2A rs4998386_T allele than in CC homozygotes [5]
The GWAIS was conducted using the NeuroGenetics Research Consortium (NGRC) dataset, which is a single dataset of 1,458 cases and 931 controls with complete genotype and exposure data collected using NGRC’s uniform study design and protocols
There are currently nine datasets in the literature that have examined PD risk as a function of GRIN2A and coffee use: four have statistically significant evidence in favor of GRIN2A being a modifier of PD– coffee association (NGRC, PAGE, Sweden, and Denmark) and three show a consistent trend towards interaction (HIHG, PEG, and France)

Summary

Introduction

The first evidence for involvement of glutamate receptor gene GRIN2A came from a genome-wide association and interaction study (GWAIS) that suggested that the protective effect of coffee against PD is stronger in carriers of GRIN2A rs4998386_T allele than in CC homozygotes [5]. The finding was replicated with statistical significance in the PAGE dataset (Parkinson’s, Genes, and Environment from the prospective National Institutes of Health [NIH]-AARP Diet and Health Study cohort [6]), which is a single uniformly collected dataset of 525 cases and 1,474 controls.

Results

Conclusion