Glutamate-induced cell death in neuronal HT22 cells is attenuated by extracts from St. John's wort (Hypericum perforatum L.)

Anja Breyer,Erich Elstner,Thomas Gillessen,Matthias Elstner,Dieter Weiser

doi:10.1016/j.phymed.2007.02.001

Glutamate-induced cell death in neuronal HT22 cells is attenuated by extracts from St. John's wort (Hypericum perforatum L.)

Anja Breyer, Erich Elstner + Show 3 more

https://doi.org/10.1016/j.phymed.2007.02.001

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Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology	Publication Date: Mar 7, 2007
Citations: 34

Affiliation: Technical University of Munich, Bundeswehr Medical Service Academy, Ludwig-Maximilians-Universität München

#Hypericum Perforatum #Neuronal HT22 Cells + Show 8 more

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Abstract

Glutamate-induced cell death of hippocampal HT22 cells is a model system for neuronal disorders due to depletion of glutathione levels and increase of intracellular reactive oxygen species. Standardized extracts of Hypericum perforatum (HPE) contain flavonoids known for antioxidative properties. In the above model, cytoprotective effects at a concentration of 0.05% HPE by attenuation of calcium fluxes and cellular energy statuses are reported.

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