Abstract
Summary.This report points out the more extensive biochemical significance to the elucidation of the production and mechanism of action of l‐ascorbic acid which may be derived from a detailed study of the glucuronic acid metabolism of the guinea pig.To supplement the deficient information in the literature on the glucuconic acid metabolism of the guinea pig, determinations were made of the glucuronic acid concentration of guinea pig whole blood and serum and the total amount of glucuronic acid daily eliminated into the urine. It was demonstrated that when necessary for the detoxication of a foreign substance the guinea pig is carable of very considerably increasing the glucuronic acid synthesis. In studying the relationship between scurvy and glucuronic acid metabolism it was observed that scurvy seems to have at least no reducing effect on the normal concentrations in the blood and urine. On the contrary, it appeared probable that a tedency to somewhat increasing serum glucuronic acid levels occurred in scurvy.
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