Abstract
ABSTRACT The crude ethanolic extracts of different parts (root, stem, leaves and flower) of Lysiphyllum strychnifolium were tested for α-glucosidase inhibitory and antioxidant activities. Since all extracts showed good inhibitory activity, active constituents were isolated. Thirteen known compounds, including three dihydroflavanones, three dihydrochalcones, two stilbenes, flavan-3-ol, flavonol, cyclitol, phenolic ethyl ester and phenolic acid were isolated, and their α-glucosidase inhibitory effect and antioxidant activity were evaluated. Phloretin 4’-O-(6”-O-galloyl)-β-D-glucoside from the leaves extract showed potent α-glucosidase inhibitory activity (IC50 = 0.0162 ± 0.0014 mM) and potent antioxidant activity (IC50 = 19.26 ± 0.95 μM), each more potent than the positive controls. The compounds were investigated for their structure–activity relationship (SAR) in both activities. The number and position of hydroxy groups seemed to play a crucial role in increasing α-glucosidase inhibitory and antioxidant activities.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
