Abstract
The leaves of guava and cashew have widely used as antidiabetic. Mechanism of antidiabetic effect on guava and cashew leaf caused by inhibition of α-glucosidase. More over antioxidant activity of guava and cashew leaf are expected decreased risk of DM complications by stop oxidative stress process. This study aimed to analyze the activity of α-glucosidase inhibitor and antioxidant of guava and cashew leaves This study use in vitro model with spectrophotometric method to analyze sample with λ= 517 nm for antioxidant analyze and λ= 405 nm for activity of α-glucosidase inhibitor. The data were analyzed by Analysis of Variance (ANOVA) and Least Significant Difference (LSD) on the real level of 1% and 5% The result showed that guava leaf extract has the highest α-glucosidase inhibitor activity by 97,006 % inhibition with IC50 = 2,16 mg/ml and antioxidant activity by 97,992 % on scavenging DPPH. The combination of guava leaf extract and cashew leaf extract did not give some effect on antioxidant activity or αglucosidase inhibitor activity. The extract of guava and cashew leaves have α-glucosidase inhibitor activity and antioxidant activity. Combination of the extracts did not give some effect on antioxidant activity or α-glucosidase inhibitor activity.
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