Abstract
The glucose-6-phosphate dehydrogenase (G6PD) deficiency status of the Papua New Guinea populations is unique from the other populations of the world. We have already presented evidence for the existence of significant biochemical heterogeneity of the G6PD mutants in Papua New Guinea. We have now characterized 10 additional cases of G6PD deficiency in adult males from different regions of Papua New Guinea. Three of these cases were found to be examples of previously described variants (Markham, Salata and Kaluan). Four new variant types have been characterized. Like all previously described G6PD variants from Papua New Guinea these new variants do not exhibit significant levels of activity with the WH037 assay and do not present any evidence of chronic haemolytic anaemia. The biochemical characteristics of these new variants and their distribution in Papua New Guinea will be described.
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