Abstract

Aqueous extract of the whole plant of Phyllanthus amarus was assessed for some biochemical effect in albino rats. Oral administration of aqueous extract at doses of 50, 100 and 200 mg/kg body weight shows that the extract promote glucose uptake. Daily administration of the extracts (50, 100 and 200 mg/kg bodyweight) for 14 days showed that the extract significantly (p 0.05) change on the creatinine and triacyiglycerol (TAG) concentration for all the animal administered the extract compared with the control. The concentration of total cholesterol was significantly (p < 0.05) reduced for all the concentrations; the reduction was found to be dose dependant. The atherogenic index Log (TG/HDL-CH) of the animals showed no significant differences between tests and control. These findings may be of clinical importance to individuals at risk of cardiovascular disease.

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