Abstract
A superfusion model was used to study in vitro gastric inhibitory polypeptide (GIP) release from hamster small intestinal mucosa. A 10% glucose solution, in both fed and fasted hamsters, produced a prompt, sustained, three-fold rise in mean GIP release. In contrast, superfusion of a solution of 10% mannitol did not alter release of the peptide. This model provides potential for elucidation of the mechanisms through which glucose and other agents release GIP and other gastrointestinal peptides.
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