Abstract
In this work, we demonstrate in vitro detection of glucose by means of a lab-on-chip absorption spectroscopy approach. This optical method allows label-free and specific detection of glucose. We show glucose detection in aqueous glucose solutions in the clinically relevant concentration range with a silicon-based optofluidic chip. The sample interface is a spiral-shaped rib waveguide integrated on a silicon-on-insulator (SOI) photonic chip. This SOI chip is combined with micro-fluidics in poly(dimethylsiloxane) (PDMS). We apply aqueous glucose solutions with different concentrations and monitor continuously how the transmission spectrum changes due to glucose. Based on these measurements, we derived a linear regression model, to relate the measured glucose spectra with concentration with an error-of-fitting of only 1.14 mM. This paper explains the challenges involved and discusses the optimal configuration for on-chip evanescent absorption spectroscopy. In addition, the prospects for using this sensor for glucose detection in complex physiological media (e.g. serum) is briefly discussed.
Highlights
Diabetes is a serious health condition that requires patients to self-monitor their blood glucose levels
We propose an implantable continuous glucose monitoring (CGM) device that detects glucose based on NIR absorption spectroscopy
The developed system demonstrates that sensitive and selective molecular detection is possible without the need of any labeling or selective-binding chemistry which is common practice for on-chip sensors [16]. All of this is a first step towards an in vivo CGM device, but it will be clear from the paper that many challenges remain before a silicon-photonics-based approach will enable CGM
Summary
Diabetes is a serious health condition that requires patients to self-monitor their blood glucose levels. To implement the implantable CGM device, we need a miniature spectrometer This is possible by integrating the spectrometer functionality on a silicon-on-insulator (SOI) photonic chip. The developed system demonstrates that sensitive and selective molecular detection is possible without the need of any labeling or selective-binding chemistry which is common practice for on-chip sensors [16]. All of this is a first step towards an in vivo CGM device, but it will be clear from the paper that many challenges remain before a silicon-photonics-based approach will enable CGM. We provide an outlook and conclusion based on the obtained results
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