Glucose-responsive microhydrogels based on methacrylate modified dextran/concanavalin A for insulin delivery

Abstract

Summary Glucose-responsive microhydrogels based on methacrylate derivatives of dextran and concanavalin A have been prepared and used for self-regulated insulin delivery. Insulin release from these microhydrogels was in response to different glucose concentrations in the medium and the glucose sensitivity was reversible. The released insulin was proved to remain active without destroying the tertiary structure. The degree of substitution (DS) of the dextran methacrylate derivative had effect on the glucose sensitivity of the microhydrogels.