Abstract
Based on the traditional view of energy drop as a key trigger for ischemia-induced cell death, various nutritional strategies including glucose supplementation were developed to maintain epithelial barrier integrity. Our recent finding indicated that glycolytic pyruvate was responsible for the rescue of epithelial cell death in an energy-independent manner. In contrast, ATP promoted crypt proliferation but failed to protect against villous cell death. This study challenges the classical view and supports that energy depletion is not the cause but an effect of epithelial cell death under ischemic stress.
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