Abstract
The oxidation of uniformly labeled C14-glucose by normal mice and mice infected with strain MEF1 poliomyelitis virus was determined in an apparatus designed to measure respiratory radioactivity excretion. The respiration of normal and virus-infected mice was found to be essentially the same over a 10-day period of infection, although the production of virus in the diseased animal during this time was considerable. It is concluded that the rate and extent of viral multiplication in poliomyelitis is without apparent effect on the rate and extent of glucose metabolism by the infected intact host.
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