Abstract
The pathways of glucose metabolism in lymphatic tissues of immature rats were examined enzymatically during periods of exercise-induced, elevated corticosteroid secretion. Acute exercise (10 hours) of untrained rats increased corticosterone levels 230% above controls, caused a moderate arrest of thymus and spleen growth, decreased thymus GPT and LDH activity 15–25% below controls, and increased spleen MDH activity 25%. Acute exercise of trained rats increased corticosterone secretion only 116% above controls, but caused a marked arrest of lymphatic tissue growth and a variety of changes in tissue enzyme activity. These included increases in GPT and MDH, reciprocal changes in LDH and α-GPD, and decreases in G6PD and 6-PGD activity. The pattern of enzymatic response was interpreted as a hormonally mediated regulatory mechanism to divert substrate (glucose-6-phosphate) from the hexose monophosphate shunt to glycolysis during periods of suboptimal lymphatic tissue growth.
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