Abstract
ObjectiveTo determine the relationship between tumor glucose metabolism and tumor blood flow (TBF) in head and neck squamous cell carcinoma (HNSCC).MethodsWe retrospectively analyzed 57 HNSCC patients. Tumor glucose metabolism was assessed by maximum and mean standardized uptake values (SUVmax and SUVmean) obtained by 18F-fluorodeoxyglucose positron-emission tomography. TBF values were obtained by arterial spin labeling with 3-tesla MRI. The correlations between both SUVs and TBF were assessed in the total series and among patients divided by T-stage (T1–T3 and T4 groups) and tumor location (pharynx/oral cavity and sinonasal cavity groups). Pearson’s correlation coefficients were calculated for significant correlations.ResultsSignificant correlations were detected: a negative correlation in the advanced T-stage group (TBF and SUV max: r, −0.61, SUVmean: r, −0.62), a positive correlation in the non-advanced T-stage pharynx/oral cavity group (TBF and SUVmax: r, 0.70, SUVmean: r, 0.73), a negative correlation in the advanced T-stage pharynx/oral cavity group (TBF and SUVmax: r, −0.62, SUVmean: r, −0.65), and a negative correlation in the advanced T-stage sinonasal cavity group (TBF and SUVmax: r, −0.61, SUVmean: r, −0.65).ConclusionSignificant correlations between glucose uptake and TBF in HNSCC were revealed by the division of T-stage and tumor location.
Highlights
For head and neck (HN) squamous cell carcinomas (SCCs), several studies have demonstrated that tumor glucose metabolism and tumor blood flow (TBF) are important biological factors for the diagnosis and treatment, respectively [1,2,3,4]
Significant correlations between glucose uptake and TBF in head and neck squamous cell carcinoma (HNSCC) were revealed by the division of T-stage and tumor location
We retrospectively evaluated the cases of 57 patients with HNSCC with the following inclusion criteria: (1) the patient was first diagnosed histopathologically as having HNSCC, (2) both MR and Positron-emission tomography (PET)/CT scanning was performed before any treatment, and (3) the scan interval between MR and PET/CT was
Summary
For head and neck (HN) squamous cell carcinomas (SCCs), several studies have demonstrated that tumor glucose metabolism and tumor blood flow (TBF) are important biological factors for the diagnosis and treatment, respectively [1,2,3,4]. The tumor metabolic rate is one of the important factors that reflect tumor aggressiveness, and the determination of a tumor’s FDG uptake has been reported to improve the accuracy of the diagnosis, staging, and detection of recurrence in HNSCCs [1, 2]. The recent use of the arterial spin labeling (ASL) technique has allowed the noninvasive measurement of the tissue blood flow even in head and neck lesions [5,6,7]. With the ASL technique, we have been able to measure TBF more due to its noninvasiveness compared to the dynamic contrastenhanced technique
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