Abstract
Abstract Fed-batch culture employing the DO-stat method was carried out to produce recombinant human interleukin-2 in Escherichia coli . The concentration of interleukin-2 and final cell density in the fed-batch culture were 1.02 g/ l and 60 OD (optical density), respectively. This represents a significant improvement in interleukin-2 production and final cell density over the equivalent values of batach fermentation.
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