Abstract
Glycemic control is essential to manage metabolic diseases such as diabetes. Frequent measurements of systemic glucose levels with prompt managements can prevent organ damages. The eye is a glucose highly demanding organ in our body, and the anterior chamber (AC) in the eye has been suggested for a noninvasive blood glucose monitoring site. However, calculating blood glucose levels from measuring glucose levels in AC has been difficult and unclear. In this study, we aimed to examine glucose levels from AC and find a correlation with blood glucose levels. A total of 30 patients with cataracts (men and women, study 1; 7 and 3, study 2; 9 and 11) who visited Keio University Hospital from 2015 to 2018 and agreed to participate in this study were recruited. Glucose levels from AC and the blood were examined by a UV-hexokinase or H2O2-electrode method before/during the cataract surgery. These values were analyzed with regression analyses depending on the groups (blood glucose-ascending and descending groups). In the blood glucose-descending group, glucose levels from AC were strongly correlated with blood glucose levels (a high R2 value, 0.8636). However, the relatively moderate correlation was seen in the blood glucose-ascending group (a low R2 value, 0.5228). Taken together, we showed different correlation ratios on glucose levels between AC and the blood, based on blood glucose dynamics. Stacking data regarding this issue would enable establishing noninvasive blood glucose monitoring from measuring glucose levels in AC more correctly, which will be helpful for proper and prompt managements for glucose-mediated complications.
Highlights
Glycemic control is considered important for metabolic diseases such as diabetes mellitus [1]
Repetitive punctures can damage chronic nerve fibers at the measurement sites [5], and production of biohazardous wastes after testing can be another issue for the environment. In consideration of these matters, a generation of a testing method came to the surface on medical equipment fields, termed “continuous glucose monitoring (CGM) devices” [6]
CGM devices are mainly inserted in the abdomen, and their probe tubes are placed in the body [6]
Summary
Glycemic control is considered important for metabolic diseases such as diabetes mellitus [1]. When patients need to know their blood glucose levels, they puncture their hands (usually, fingers), put the blood sample to the testing gadgets, and blood glucose levels are immediately determined [5], which is very easy to use Their methods can cause fear of testing, pain and scarring after testing [5]. Repetitive punctures can damage chronic nerve fibers at the measurement sites [5], and production of biohazardous wastes after testing can be another issue for the environment In consideration of these matters, a generation of a testing method came to the surface on medical equipment fields, termed “continuous glucose monitoring (CGM) devices” [6]. Even though there have been several developments for glucose level testing, noninvasive and effective methods are still highly on demand
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
