Glucose/insulin metabolism and vitamin D in women with recurrent pregnancy loss.

Abstract

Glucose/insulin metabolism has been related to recurrent pregnancy loss (RPL) through mechanisms not really clarified. Also, vitamin D deficiency seems to be associated to RPL. The purpose of our study was to evaluate the correlation between glucose/insulin metabolism parameters and vitamin D levels in women with history of RPL. Observational retrospective study on RPL women. The correlation among vitamin D levels and fasting glucose (FG), fasting insulin (FI), Homeostatic model assessment of insulin resistance (HOMA-IR) index, area under glucose curve (AUC-Glyc) and area under insulin curve (AUC-Ins), was evaluated. One-hundred and twenty-seven RPL women were classified into three subgroups (0-1-2) according to the levels of FI. We found a statistically significant linear Pearson correlation between FI and HOMA-IR (r=.840; P=.001). An, inverse, but non-significant correlation both between vitamin D and FI (R=-.202, ns) and vitamin D levels and AUC-Ins (R=-.288, ns) was observed. The variables vitamin D, HOMA-IR and AUC-Ins were statistically significant in the considered subgroups (Vitamin D: ANOVA + Bonferroni test: 0vs. 1; P=.001; 0vs. 2; P=.010; 1vs. 2; P=.657; HOMA-IR: ANOVA + Bonferroni test: 0vs. 1; P=.014; 0vs. 2; P=.001; 1vs. 2; P=.001; AUC-Ins: ANOVA + Bonferroni test: 0vs. 1; P=.010; 0vs. 2; P=.206; 1vs. 2; P=.980). Vitamin D might play additional roles in the pathogenesis of RPL, beyond its well known immunomodulatory role.