Abstract
We tested whether glucose rate of appearance (Ra), disappearance (Rd), and metabolic clearance rate (MCR) would remain elevated following exercise. 10 men and 8 women received a primed‐continuous infusion of [6,6‐2H2]glucose tracer to measure glucose kinetics under 3 different conditions: 1) before, during and 3 h after 90 min of exercise at 45% VO2peak (E45), 2) before, during, and 3 h after 60 min of exercise at 65% VO2peak (E65), and 3) in a time‐matched sedentary control trial (C). Glucose Ra, Rd, MCR, and carbohydrate oxidation (CHOox) declined in C from the pre‐exercise time points to those corresponding to post‐exercise recovery in both men and women (P < 0.05). In men and women, Ra, Rd, and MCR increased above C during exercise and were higher in E65 than E45 (p < 0.05). Average Ra, Rd, and MCR remained elevated above C over 3 h of post‐exercise recovery in men following exercise in E45 and E65 (P < 0.05). In contrast, average Ra and Rd did not remain significantly elevated during post‐exercise recovery in women, although MCR did remain significantly elevated in E65 in women during post‐exercise recovery (P < 0.05). During post‐exercise recovery, CHOox was lower than in C in both sexes (P < 0.05). Depressed CHOox with elevated glucose disposal (men) or maintained glucose disposal (women), characterizes post‐exercise recovery as a time of CHO mobilization and partitioning toward non‐oxidative disposal. NIH grant AR 42906.
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